Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2200189 | 1.00 | MCHR1 (0.42) | MCHR1EPHX2SPRKMT2AKDM4E | |
| SCHEMBL12429475 | 1.00 | MCHR1 (0.42) | MCHR1EPHX2SPRKMT2AKDM4E | |
| SCHEMBL2200184 | 1.00 | MCHR1 (0.42) | MCHR1EPHX2SPRKMT2AKDM4E | |
| SCHEMBL2200653 | 0.95 | EPHX2 (0.47) | MCHR1EPHX2KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200656 | 0.95 | EPHX2 (0.47) | MCHR1EPHX2KMT2AKDM4EALDH1A1 | |
| SCHEMBL2200314 | 0.88 | KMT2A (0.44) | EPHX2KMT2AMAPTMEN1L3MBTL1 | |
| SCHEMBL2200316 | 0.88 | KMT2A (0.44) | EPHX2KMT2AMAPTMEN1L3MBTL1 | |
| SCHEMBL2201497 | 0.87 | KMT2A (0.43) | KMT2ALMNAMEN1L3MBTL1 | |
| SCHEMBL2201503 | 0.87 | KMT2A (0.43) | KMT2ALMNAMEN1L3MBTL1 | |
| SCHEMBL2201732 | 0.85 | MALT1 (0.40) | MCHR1KMT2AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |