Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | GLA | P06280 | 4/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219274 | 0.84 | KDM4E (0.67) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL13839168 | 0.82 | KDM4E (0.65) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL220134 | 0.81 | KDM4E (0.78) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL20767988 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL68231 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL24025684 | 0.77 | KDM4E (0.68) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL8863327 | 0.75 | KDM4E (0.65) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL13609430 | 0.74 | KDM4E (0.64) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL29651337 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAAGLA | |
| SCHEMBL335474 | 0.73 | KDM4E (1.00) | KDM4EALDH1A1HPGDGAAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790536-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170233426-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2017-08-17 | — | — | US | disclosed |
| US-9481701-B2 | Method for 2-sulfation of glycosides | UNIVERSITY OF WASHINGTON (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150158900-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2015-06-11 | — | — | US | disclosed |
| US-8802833-B2 | Method for 2-sulfation of glycosides | UNIVERSITY OF WASHINGTON (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2385950-B1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIV WASHINGTON (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2191006-B1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIV WASHINGTON (US) | 2012-11-21 | — | — | EP | disclosed |
| US-8088745-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110288281-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2385950-A2 | METHOD FOR 2-SULFATION OF GLYCOSIDES | University Of Washington (US) | 2011-11-16 | — | — | EP | disclosed |
| US-8039496-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2010-08-19 | — | — | US | disclosed |
| WO-2010081163-A2 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2010-07-15 | — | — | WO | disclosed |
| EP-2191006-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | University of Washington (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026252-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885HPGD 1422/4885 |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885HPGD 1422/4885 |
| US-20110288281-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885HPGD 449/4885 |
| US-20150158900-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885HPGD 449/4885 |
| US-20170233426-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885HPGD 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.