Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | GAA | P10253 | 3/20 | 0.67 |
| ▸ | GLA | P06280 | 3/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | GRB2 | P62993 | 1/20 | 0.62 |
| ▸ | HSD17B3 | P37058 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL220020 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL4209634 | 0.84 | KDM4E (0.76) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL533173 | 0.81 | ALDH1A1 (1.00) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL29115101 | 0.78 | ALDH1A1 (0.70) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL10313775 | 0.78 | KDM4E (0.63) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL263980 | 0.77 | AKR1B1 (1.00) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL16601626 | 0.77 | KDM4E (0.62) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL10313774 | 0.77 | KDM4E (0.65) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL13840541 | 0.76 | AKR1B1 (0.76) | KDM4EALDH1A1GAAGLALCK | |
| SCHEMBL723839 | 0.76 | LCK (0.76) | KDM4EALDH1A1GAAGLALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790536-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170233426-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2017-08-17 | — | — | US | disclosed |
| US-9481701-B2 | Method for 2-sulfation of glycosides | UNIVERSITY OF WASHINGTON (US) | 2016-11-01 | — | — | US | disclosed |
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2015-12-10 | — | — | US | disclosed |
| US-20150158900-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2015-06-11 | — | — | US | disclosed |
| US-8802833-B2 | Method for 2-sulfation of glycosides | UNIVERSITY OF WASHINGTON (US) | 2014-08-12 | — | — | US | disclosed |
| EP-2385950-B1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIV WASHINGTON (US) | 2014-03-12 | — | — | EP | disclosed |
| EP-2191006-B1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIV WASHINGTON (US) | 2012-11-21 | — | — | EP | disclosed |
| US-8088745-B2 | Methods for assaying alpha-L-iduronidase enzymatic activity | UNIVERSITY OF WASHINGTON (US) | 2012-01-03 | — | — | US | disclosed |
| US-20110288281-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2011-11-24 | — | — | US | disclosed |
| EP-2385950-A2 | METHOD FOR 2-SULFATION OF GLYCOSIDES | University Of Washington (US) | 2011-11-16 | — | — | EP | disclosed |
| US-8039496-B2 | Therapeutic compounds | ALLERGAN, INC. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2010-08-19 | — | — | US | disclosed |
| WO-2010081163-A2 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UNIVERSITY OF WASHINGTON (US) | 2010-07-15 | — | — | WO | disclosed |
| EP-2191006-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | University of Washington (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009026252-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | UNIVERSITY OF WASHINGTON (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150353985-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885GAA 2/4885 |
| US-20100209951-A1 | METHODS FOR ASSAYING ALPHA-L-IDURONIDASE ENZYMATIC ACTIVITY | IDUA, GAA, ENGASE | KDM4E 4238/4885ALDH1A1 367/4885GAA 2/4885 |
| US-20110288281-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885GAA 80/4885 |
| US-20150158900-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885GAA 80/4885 |
| US-20170233426-A1 | METHOD FOR 2-SULFATION OF GLYCOSIDES | UGT8, STS, ST6GAL1 | KDM4E 4025/4885ALDH1A1 1844/4885GAA 80/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.