Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.62 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.62 |
| ▸ | CASR | P41180 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21735537 | 0.88 | GRIK1 (0.51) | GRIK1GRIK2CASRKDM4EALDH1A1 | |
| SCHEMBL11527498 | 0.83 | GRIK1 (0.53) | GRIK1GRIK2CASRKDM4EALDH1A1 | |
| SCHEMBL21244769 | 0.82 | MEN1 (0.55) | GRIK1GRIK2NPC1RAB9AMEN1 | |
| SCHEMBL21244768 | 0.80 | NR1I2 (0.48) | GRIK1GRIK2KDM4EALDH1A1ACLY | |
| SCHEMBL8942111 | 0.80 | GRIK1 (0.67) | GRIK1GRIK2KDM4EALDH1A1HPGD | |
| SCHEMBL22005071 | 0.80 | ACLY (0.47) | GRIK1GRIK2CASRKDM4EALDH1A1 | |
| SCHEMBL11703292 | 0.79 | KMT2A (0.59) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL22004367 | 0.79 | CYP11B1 (0.42) | GRIK1GRIK2KDM4EALDH1A1HPGD | |
| SCHEMBL22003798 | 0.79 | ACLY (0.44) | ACLYMAPTKMT2A | |
| SCHEMBL2418905 | 0.79 | ALDH1A1 (0.40) | GRIK1GRIK2CASRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | GRIK1 1471/4885GRIK2 1910/4885CASR 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.