Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21795793 | 0.84 | SMN1; SMN2 (0.46) | KCNH2SMN1; SMN2SLC18A3LMNATP53 | |
| SCHEMBL21795779 | 0.84 | DUSP3 (0.38) | KCNH2SMN1; SMN2MAPT | |
| SCHEMBL22736231 | 0.82 | NPC1 (0.41) | SLC18A3HTR2AHTR2CKMT2AMEN1 | |
| SCHEMBL29480699 | 0.80 | NPSR1 (0.53) | SMN1; SMN2SLC18A3LMNATP53MAPT | |
| SCHEMBL22716934 | 0.80 | NPSR1 (0.53) | SMN1; SMN2SLC18A3LMNATP53MAPT | |
| SCHEMBL29480691 | 0.76 | KMT2A (0.51) | KMT2A | |
| SCHEMBL21795781 | 0.76 | KMT2A (0.51) | KMT2A | |
| SCHEMBL11107232 | 0.76 | HTR2A (0.68) | SMN1; SMN2LMNAHTR2AHTR2CHTR7 | |
| SCHEMBL22003706 | 0.76 | MEN1 (0.54) | SLC18A3KMT2ATSHRMEN1 | |
| SCHEMBL29480726 | 0.76 | MEN1 (0.54) | SLC18A3KMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | Zhang, Fuyao (CN) | 2021-11-23 | — | — | US | disclosed |
| EP-3620456-B1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | ZHANG FUYAO (CN) | 2021-11-17 | — | — | EP | disclosed |
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | SHANGHAI BEST-LINK BIOSCIENCE, LLC (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155550-A1 | COMPOUND WITH KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF | CDK9, CDK7, CDK6 | KCNH2 2223/4885SMN1; SMN2 2256/4885SLC18A3 4032/4885 |
| US-11179391-B2 | Compound with kinase inhibitory activity and preparation method and use thereof | CDK9, CDK7, CDK6 | KCNH2 2223/4885SMN1; SMN2 2256/4885SLC18A3 4032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.