Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ACLY | P53396 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | FASN | P49327 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6707155 | 0.86 | MAPT (0.46) | ACLYALDH1A1HPGDL3MBTL1NPC1 | |
| SCHEMBL13940626 | 0.84 | KMT2A (0.59) | KMT2AALDH1A1HPGDFGFR1NPC1 | |
| SCHEMBL978319 | 0.83 | PTGER4 (0.51) | KMT2AACLYALDH1A1HPGDL3MBTL1 | |
| SCHEMBL22004147 | 0.83 | ACLY (0.50) | ACLYCYP19A1ALDH1A1HPGDL3MBTL1 | |
| SCHEMBL10746787 | 0.83 | HPGD (0.64) | KMT2AALDH1A1HPGDL3MBTL1GLA | |
| SCHEMBL22887215 | 0.82 | KMT2A (0.56) | KMT2AALDH1A1HPGDNPC1KDM4E | |
| SCHEMBL6478331 | 0.82 | MAPT (0.62) | ALDH1A1HPGDL3MBTL1TDP1NPC1 | |
| SCHEMBL27485997 | 0.78 | ALDH1A1 (0.47) | ACLYALDH1A1HPGDL3MBTL1GLA | |
| SCHEMBL553819 | 0.78 | MEN1 (0.54) | KMT2AALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL22005113 | 0.77 | FASN (0.58) | KMT2AACLYCYP19A1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | KMT2A 1976/4885ACLY 1/4885CYP19A1 1310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.