Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 7/20 | 0.55 |
| ▸ | FYN | P06241 | 4/20 | 0.40 |
| ▸ | ERN1 | O75460 | 4/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22004303 | 0.87 | ACLY (0.59) | ACLY | |
| SCHEMBL22004300 | 0.87 | ACLY (0.56) | ACLYMDM2TP53GFER | |
| SCHEMBL22021593 | 0.85 | ACLY (0.58) | ACLYFYNERN1GFERBRD4 | |
| SCHEMBL22004310 | 0.82 | ACLY (0.50) | ACLYFYNTP53 | |
| SCHEMBL22004309 | 0.82 | ACLY (0.58) | ACLYFYNERN1 | |
| SCHEMBL22021594 | 0.78 | ACLY (0.55) | ACLYGFER | |
| SCHEMBL22003798 | 0.77 | ACLY (0.44) | ACLY | |
| SCHEMBL22003807 | 0.77 | ACLY (0.47) | ACLY | |
| SCHEMBL22004112 | 0.76 | ACLY (0.57) | ACLY | |
| SCHEMBL22003812 | 0.75 | ACLY (0.50) | ACLYFYNTP53BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | ACLY 1/4885FYN 4726/4885ERN1 1894/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.