Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | PHGDH | O43175 | 2/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22005087 | 0.84 | ACLY (0.57) | ACLYKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL22004300 | 0.79 | ACLY (0.56) | ACLYGFERPHGDH | |
| SCHEMBL22004311 | 0.78 | ACLY (0.55) | ACLYGFER | |
| SCHEMBL22004305 | 0.77 | ACLY (0.47) | ACLYKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL22003798 | 0.73 | ACLY (0.44) | ACLYKMT2AMAPTPHGDH | |
| SCHEMBL22004310 | 0.71 | ACLY (0.50) | ACLYKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL12583871 | 0.70 | KMT2A (0.54) | ACLYKMT2AALDH1A1MEN1HPGD | |
| SCHEMBL22004112 | 0.69 | ACLY (0.57) | ACLYPHGDH | |
| SCHEMBL22004303 | 0.69 | ACLY (0.59) | ACLYPHGDHPTGER1 | |
| SCHEMBL988193 | 0.68 | SLC6A4 (0.53) | ACLYKMT2AALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102616-A1 | ACLY INHIBITORS AND USES THEREOF | Nimbus Artemis, Inc. (US) | 2020-05-22 | — | — | WO | disclosed |