Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.51 |
| ▸ | UBE2M | P61081 | 7/20 | 0.49 |
| ▸ | DCUN1D1 | Q96GG9 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30470488 | 0.88 | MEN1 (0.52) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL29081218 | 0.88 | KMT2A (0.56) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL13202810 | 0.84 | KMT2A (0.63) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL32689291 | 0.84 | MEN1 (0.48) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL22004375 | 0.83 | KMT2A (0.54) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL9533470 | 0.80 | KMT2A (0.77) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL25923489 | 0.80 | KMT2A (0.51) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL24365158 | 0.78 | NPC1 (0.60) | TP53DRD2ACLYSMN1; SMN2MAPT | |
| SCHEMBL31145098 | 0.78 | KMT2A (0.52) | KMT2AMEN1ALDH1A1TP53DRD2 | |
| SCHEMBL32689327 | 0.78 | NPC1 (0.60) | TP53DRD2ACLYSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | NIMBUS DISCOVERY, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200157076-A1 | ACLY INHIBITORS AND USES THEREOF | ACLY, ATP5ME, ATP5MG | KMT2A 1976/4885MEN1 3767/4885ALDH1A1 1455/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.