Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24365158 | 1.00 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL30753156 | 0.86 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL25322458 | 0.84 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL24364965 | 0.82 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL30469792 | 0.82 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL24365825 | 0.81 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL30470952 | 0.81 | NPC1 (0.55) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL24365159 | 0.79 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 | |
| SCHEMBL22004378 | 0.78 | KMT2A (0.58) | SMN1; SMN2NPSR1ACLYDRD2MAPT | |
| SCHEMBL31145106 | 0.78 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2NPSR1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260078117-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS INC (US) | 2026-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260078117-A1 | COMPOUNDS AND METHODS OF USE | NR3C2, ADRA1A, CNR1 | NPC1 24/4885RAB9A 420/4885SMN1; SMN2 1645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.