Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 14/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 11/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14789886 | 0.85 | CYP11B1 (0.57) | CYP11B2CYP11B1 | |
| SCHEMBL31259968 | 0.85 | CYP11B1 (0.57) | CYP11B2CYP11B1 | |
| SCHEMBL22005290 | 0.80 | CYP11B2 (0.51) | CYP11B2CYP11B1 | |
| SCHEMBL22004705 | 0.79 | CYP11B2 (0.46) | CYP11B2CYP11B1KCNH2GRIN2B | |
| SCHEMBL21535156 | 0.78 | CYP11B2 (0.40) | CYP11B2CYP11B1KCNH2 | |
| SCHEMBL22004749 | 0.77 | CYP11B2 (0.39) | CYP11B2CYP11B1 | |
| SCHEMBL21535153 | 0.77 | KLKB1 (0.38) | CYP11B2CYP11B1 | |
| SCHEMBL31260090 | 0.74 | CYP11B1 (0.58) | CYP11B2CYP11B1 | |
| SCHEMBL14789884 | 0.74 | CYP11B1 (0.58) | CYP11B2CYP11B1 | |
| SCHEMBL14789885 | 0.72 | CYP11B1 (0.57) | CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653618-A1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2020-05-20 | — | — | EP | disclosed |