Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 19/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 19/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.43 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22004719 | 0.88 | CYP11B2 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL14789950 | 0.84 | CYP11B2 (0.55) | CYP11B1CYP11B2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL31259961 | 0.84 | CYP11B2 (0.55) | CYP11B1CYP11B2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL21535322 | 0.82 | CYP11B1 (0.59) | CYP11B1CYP11B2 | |
| SCHEMBL21535180 | 0.82 | CYP11B2 (0.45) | CYP11B1CYP11B2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL14780277 | 0.82 | BMPR1B (0.48) | CYP11B1CYP11B2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL22005286 | 0.82 | CYP11B1 (0.60) | CYP11B1CYP11B2 | |
| SCHEMBL22004683 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL22005312 | 0.81 | CYP11B1 (0.58) | CYP11B1CYP11B2 | |
| SCHEMBL22004493 | 0.75 | CYP11B2 (0.49) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653618-A1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2020-05-20 | — | — | EP | disclosed |