Sugi Predict

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SCHEMBL2200610

SCHEMBL2200610

CCOC(=O)Nc1ccccc1Nc1ccc(C(=O)c2cc(C(=O)N(O)CC)ccc2C)c(Cl)c1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK14 Q16539 13/20 0.72
▸ MAPK13 O15264 12/20 0.72
▸ MAPK12 P53778 12/20 0.72
▸ MAPK11 Q15759 12/20 0.72
▸ ALDH1A1 P00352 1/20 0.42
▸ MEN1 O00255 1/20 0.40
▸ KMT2A Q03164 1/20 0.40
▸ LMNA P02545 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ MAPK1 P28482 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ KDR P35968 3/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ EGFR P00533 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2201711 0.86 MAPK13 (0.52) MAPK14MAPK13MAPK12MAPK11ALDH1A1
SCHEMBL6393200 0.84 MAPK14 (1.00) MAPK14MAPK13MAPK12MAPK11ALDH1A1
SCHEMBL2200606 0.83 MAPK14 (0.70) MAPK14MAPK13MAPK12MAPK11ALDH1A1
SCHEMBL2198875 0.83 MAPK14 (0.53) MAPK14MAPK13MAPK12MAPK11LMNA
SCHEMBL6402344 0.77 MAPK14 (0.86) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL2199713 0.76 MAPK14 (0.54) MAPK14MAPK13MAPK12MAPK11LMNA
SCHEMBL2201115 0.75 MAPK14 (0.81) MAPK14MAPK13MAPK12MAPK11MEN1
SCHEMBL6394634 0.75 MAPK14 (0.80) MAPK14MAPK13MAPK12MAPK11ALDH1A1
SCHEMBL6393099 0.75 MAPK14 (0.77) MAPK14MAPK13MAPK12MAPK11KDR
SCHEMBL6095973 0.73 MAPK14 (0.78) MAPK14MAPK13MAPK12MAPK11MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006528597-A — — 2006-12-21 — — JP claimed
US-20060166990-A1 Novel aminobenzophenone compounds LEO PHARMA A/S (DK) 2006-07-27 — — US claimed
EP-1658263-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS Leo Pharma A/S (DK) 2006-05-24 — — EP claimed
WO-2005009940-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS LEO PHARMA A/S (DK) 2005-02-03 — — WO claimed
US-7977387-B2 Aminobenzophenone compounds LEO PHARMA A/S (DK) 2011-07-12 — — US disclosed
US-20060166990-A1 Novel aminobenzophenone compounds LEO PHARMA A/S (DK) 2006-07-27 — — US disclosed
EP-1658263-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS Leo Pharma A/S (DK) 2006-05-24 — — EP disclosed
WO-2005009940-A1 NOVEL AMINOBENZOPHENONE COMPOUNDS LEO PHARMA A/S (DK) 2005-02-03 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060166990-A1 Novel aminobenzophenone compounds NFKBIA, UACA, ALDH7A1 MAPK14 697/4885MAPK13 1063/4885MAPK12 955/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.