Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17803300 | 1.00 | REN (0.44) | RENKCNA5SIGMAR1PSEN1PSEN2 | |
| SCHEMBL31756093 | 0.82 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6548680 | 0.76 | REN (0.40) | RENKCNA5SIGMAR1PSEN1PSEN2 | |
| SCHEMBL22006159 | 0.74 | REN (0.43) | RENKCNA5IDO1AGXTNAAA | |
| SCHEMBL17803293 | 0.74 | REN (0.43) | RENKCNA5IDO1AGXTNAAA | |
| SCHEMBL17803350 | 0.74 | REN (0.39) | RENKCNA5 | |
| SCHEMBL22006158 | 0.74 | REN (0.39) | RENKCNA5 | |
| SCHEMBL19713508 | 0.74 | REN (0.39) | RENKCNA5 | |
| SCHEMBL17803356 | 0.74 | REN (0.39) | RENKCNA5 | |
| SCHEMBL15032473 | 0.71 | NAAA (0.46) | SIGMAR1IDO1AGXTMAPK1NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3226690-B1 | NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES | MERCK SHARP & DOHME (US) | 2020-05-20 | — | — | EP | disclosed |