Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 8/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201907 | 0.99 | KMT2A (0.52) | KMT2ANPSR1CYP2D6CYP2C19L3MBTL3 | |
| SCHEMBL2203158 | 0.92 | KMT2A (0.51) | KMT2ANPSR1HSD11B1MAPTRAB9A | |
| SCHEMBL2200244 | 0.92 | KMT2A (0.55) | KMT2ANPSR1MAPTRAB9AMEN1 | |
| SCHEMBL2199925 | 0.91 | KMT2A (0.50) | KMT2ANPSR1L3MBTL3L3MBTL1HSD11B1 | |
| SCHEMBL2199934 | 0.91 | KMT2A (0.48) | KMT2ANPSR1L3MBTL1HSD11B1MAPT | |
| SCHEMBL2202253 | 0.90 | L3MBTL3 (0.43) | KMT2ANPSR1CYP2D6CYP2C19L3MBTL3 | |
| SCHEMBL2201185 | 0.89 | MAPK7 (0.42) | KMT2ANPSR1CYP2D6CYP2C19L3MBTL3 | |
| SCHEMBL2197806 | 0.89 | CACNA2D1 (0.46) | KMT2AL3MBTL3L3MBTL1MBTD1 | |
| SCHEMBL2201084 | 0.89 | KMT2A (0.49) | KMT2ANPSR1HSD11B1MAPTRAB9A | |
| SCHEMBL2199358 | 0.89 | KMT2A (0.49) | KMT2ANPSR1HSD11B1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | KMT2A 4057/4885NPSR1 431/4885CYP2D6 1221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.