Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | HTR3A | P46098 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 4/20 | 0.45 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20365404 | 0.81 | KMT2A (0.53) | ACHEHTR2CHTR2BHTR2ASIGMAR1 | |
| SCHEMBL11730539 | 0.80 | ACHE (0.63) | ACHEHTR2CHTR2BHTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL11730619 | 0.79 | ACHE (0.62) | ACHEHTR2CHTR2BHTR2ASIGMAR1 | |
| SCHEMBL20128666 | 0.76 | ALDH1A1 (0.50) | ACHEHTR2CHTR2BHTR2ASIGMAR1 | |
| SCHEMBL29657194 | 0.76 | GRM5 (0.64) | ACHEHTR2CHTR2BHTR2ASIGMAR1 | |
| SCHEMBL21040315 | 0.76 | HTR2C (0.56) | HTR2CHTR2BHTR2AKMT2AKDM5A | |
| Hydrochloric Acid SCHEMBL30321070 | 0.74 | HTR2C (0.55) | HTR2CHTR2BHTR2AKMT2AKDM5A | |
| SCHEMBL20331096 | 0.74 | ACHE (0.46) | ACHEHTR3AHTR2CHTR2BHTR2A | |
| SCHEMBL28985479 | 0.73 | HTR2C (0.54) | HTR3AHTR2CHTR2BHTR2AGRM5 | |
| SCHEMBL30169468 | 0.73 | HTR2C (0.70) | ACHEHTR3AHTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155689-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | CRBN, CBL, MDM2 | ACHE 2447/4885HTR3A 3697/4885HTR2C 4128/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.