Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.50 |
| ▸ | DRD3 | P35462 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | PER2 | O15055 | 2/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4907493 | 0.79 | DRD2 (0.52) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| Trifluoroacetic Acid SCHEMBL2199631 | 0.78 | DRD2 (0.51) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL2198557 | 0.78 | DRD2 (0.59) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL12427164 | 0.73 | DRD2 (0.48) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL27716316 | 0.72 | DRD2 (0.62) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL12510232 | 0.71 | DRD2 (0.46) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL6221920 | 0.70 | RAB9A (0.69) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL18937416 | 0.70 | RAB9A (0.69) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL4919307 | 0.68 | DRD2 (0.46) | DRD2DRD3RAB9AHDAC1KCNH2 | |
| SCHEMBL8151399 | 0.67 | DRD2 (0.62) | DRD2DRD3RAB9AHDAC1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977334-B2 | N-(3-{2-[3-(6-amino-benzimidazol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide; beta(3)-Adrenoceptor agonists; antidiabetic, obesity modulator, insulin resistance | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-12 | — | — | US | disclosed |