Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24220812 | 1.00 | NR1H2 (0.40) | NR1H2DDB1CRBNNAMPTJAK1 | |
| SCHEMBL21964076 | 0.88 | NR1H2 (0.42) | NR1H2DDB1CRBNNAMPTJAK1 | |
| SCHEMBL22010419 | 0.88 | NR1H2 (0.42) | NR1H2DDB1CRBNNAMPTJAK1 | |
| SCHEMBL21964179 | 0.87 | POLB (0.31) | ALDH1A1 | |
| SCHEMBL22011473 | 0.81 | MEN1 (0.45) | NR1H2DDB1CRBNJAK1JAK2 | |
| SCHEMBL31570609 | 0.76 | NR1H2 (0.48) | NR1H2DDB1CRBNJAK1JAK2 | |
| SCHEMBL15139606 | 0.73 | NR1H2 (0.57) | NR1H2DDB1CRBNNAMPTEPHX2 | |
| SCHEMBL15171534 | 0.73 | NR1H2 (0.57) | NR1H2DDB1CRBNNAMPTEPHX2 | |
| SCHEMBL22720484 | 0.73 | NR1H2 (0.57) | NR1H2DDB1CRBNNAMPTEPHX2 | |
| SCHEMBL22010417 | 0.72 | NR1H2 (0.45) | NR1H2NAMPTHSD11B1EPHX2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |