Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22011478 | 0.89 | ALDH1A1 (0.43) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL21964052 | 0.88 | MEN1 (0.46) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL21964050 | 0.88 | MEN1 (0.46) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL24220724 | 0.88 | ALDH1A1 (0.41) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL21964069 | 0.87 | POLB (0.36) | MEN1ALDH1A1MAPTKMT2AHSD11B1 | |
| SCHEMBL28604432 | 0.85 | ALDH1A1 (0.40) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL24220747 | 0.85 | ALDH1A1 (0.39) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL28609627 | 0.82 | MEN1 (0.40) | MEN1ALDH1A1MAPTKMT2AHPGD | |
| SCHEMBL24220812 | 0.81 | NR1H2 (0.40) | MEN1ALDH1A1MAPTKMT2AUSP30 | |
| SCHEMBL22010418 | 0.81 | NR1H2 (0.40) | MEN1ALDH1A1MAPTKMT2AUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099882-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |