Sugi Predict

Sugi Predict / Compounds / SCHEMBL2201056

SCHEMBL2201056

SCHEMBL2201056

Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1-c1cc(C(C)(C)C)[nH]c(=O)c1C#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 10/20 0.43
▸ ALDH1A1 P00352 5/20 0.43
▸ HPGD P15428 5/20 0.43
▸ GLA P06280 4/20 0.43
▸ GAA P10253 4/20 0.43
▸ BIRC5 O15392 2/20 0.40
▸ CA12 O43570 3/20 0.37
▸ CA1 P00915 3/20 0.37
▸ CA9 Q16790 3/20 0.37
▸ PIM1 P11309 4/20 0.36
▸ MAPT P10636 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ TP53 P04637 1/20 0.34
▸ PREP P48147 1/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ POLB P06746 1/20 0.32
▸ APEX1 P27695 1/20 0.32
▸ RECQL P46063 1/20 0.32
▸ BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2201617 0.83 BIRC5 (0.43) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2201441 0.70 SQOR (0.40) ALDH1A1HPGDGAACA12CA1
SCHEMBL2198100 0.70 GLA (0.54) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2200660 0.69 ATM (0.51) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL15492448 0.68 ATM (0.64) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2200567 0.68 KDM4E (0.51) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2199412 0.67 KDM4E (0.54) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2201639 0.67 KDM4E (0.57) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2203022 0.67 KDM4E (0.40) KDM4EALDH1A1HPGDGLAGAA
SCHEMBL2198887 0.66 SQOR (0.41) KDM4EALDH1A1HPGDGLAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846402-B1 3-AMINO-PYRAZOLO[3,4B]PYRIDINES USED AS INHIBITORS OF PROTEIN TYROSINE KINASES FOR TREATING ANGIOGENIC, HYPERPROLIFERATIVE OR NEURODEGENERATIVE DISEASES BAYER IP GMBH (DE) 2014-02-26 — — EP disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents MAP4K2, ABL1, MAP4K3 KDM4E 1340/4885ALDH1A1 2786/4885HPGD 2273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.