Sugi Predict

Sugi Predict / Compounds / SCHEMBL2201617

SCHEMBL2201617

SCHEMBL2201617

Cc1ccc(O[Si](C)(C)C(C)(C)C)cc1-c1cc(-c2ccncc2)[nH]c(=O)c1C#N

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BIRC5 O15392 1/20 0.43
▸ KDM4E B2RXH2 6/20 0.42
▸ GLA P06280 4/20 0.42
▸ MEN1 O00255 4/20 0.42
▸ KMT2A Q03164 4/20 0.42
▸ MAPT P10636 3/20 0.42
▸ GAA P10253 3/20 0.42
▸ BLM P54132 3/20 0.42
▸ RECQL P46063 2/20 0.42
▸ POLB P06746 1/20 0.42
▸ APEX1 P27695 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ ATM Q13315 2/20 0.42
▸ PIM1 P11309 5/20 0.42
▸ PKM P14618 1/20 0.39
▸ MET P08581 1/20 0.39
▸ KDR P35968 1/20 0.39
▸ USP2 O75604 1/20 0.38
▸ HPGD P15428 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2201056 0.83 KDM4E (0.43) BIRC5KDM4EGLAMEN1KMT2A
SCHEMBL2198887 0.74 SQOR (0.41) KDM4EGLAKMT2AMAPTGAA
SCHEMBL2591224 0.73 KDM4E (0.73) KDM4EGLAMEN1KMT2AMAPT
SCHEMBL2203770 0.72 MEN1 (0.56) KDM4EGLAMEN1KMT2AMAPT
SCHEMBL2201383 0.70 PIM1 (0.55) KDM4EGLAMEN1KMT2AMAPT
SCHEMBL2201605 0.67 ATM (0.53) BIRC5KDM4EGLAMEN1KMT2A
SCHEMBL2201441 0.67 SQOR (0.40) MEN1KMT2AGAAL3MBTL1HPGD
SCHEMBL2203539 0.66 MET (0.51) KDM4EGLAMEN1KMT2AMAPT
SCHEMBL2583906 0.66 KDM4E (0.57) BIRC5KDM4EGLAGAABLM
SCHEMBL2200432 0.66 ATM (0.61) BIRC5KDM4EGLAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846402-B1 3-AMINO-PYRAZOLO[3,4B]PYRIDINES USED AS INHIBITORS OF PROTEIN TYROSINE KINASES FOR TREATING ANGIOGENIC, HYPERPROLIFERATIVE OR NEURODEGENERATIVE DISEASES BAYER IP GMBH (DE) 2014-02-26 — — EP disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-7977325-B2 3-amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents BAYER SCHERING PHARMA AG (DE) 2011-07-12 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents GENESYS CLOUD SERVICES, INC. 2009-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090030010-A1 3-Amino-pyrazolo[3,4b]pyridines as inhibitors of protein tyrosine kinases, their production and use as pharmaceutical agents MAP4K2, ABL1, MAP4K3 BIRC5 2560/4885KDM4E 1340/4885GLA 1658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.