⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL21963711 | 0.98 | KDM4E (0.38) | — | |
| SCHEMBL3827004 | 0.77 | — | — | |
| SCHEMBL291019 | 0.77 | — | — | |
| SCHEMBL28869957 | 0.77 | — | — | |
| SCHEMBL1964305 | 0.77 | — | — | |
| SCHEMBL1063211 | 0.77 | — | — | |
| SCHEMBL23675088 | 0.76 | DGAT1 (0.37) | — | |
| SCHEMBL30298923 | 0.76 | DGAT1 (0.37) | — | |
| SCHEMBL14535486 | 0.76 | ALOX15 (0.42) | — | |
| SCHEMBL12116983 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12516046-B2 | 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-01-06 | — | — | US | disclosed |
| US-20230227441-A1 | 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-07-20 | — | — | US | disclosed |
| CN-116056697-A | 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors | 默沙东有限责任公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-4167994-A1 | 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| US-20230035837-A1 | ANTIBIOTIC COMPOUNDS, METHODS OF MANUFACTURING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2023-02-02 | — | — | US | disclosed |
| WO-2021257418-A1 | 2-OXO-OXAZOLIDINE-5-CARBOXAMIDES AS NAV1.8 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | WO | disclosed |
| WO-2020099341-A1 | ANTIBIOTIC COMPOUNDS, METHODS OF MANUFACTURING THE SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF | DEBIOPHARM INTERNATIONAL S.A. (CH) | 2020-05-22 | — | — | WO | disclosed |
| CN-101282965-A | Alkoxy indolone-based protein kinase inhibitors | SCRIPPS RESEARCH INST (US) | 2008-10-08 | — | — | CN | disclosed |
| CN-101222920-A | Enhanced indolinone based protein kinase inhibitors | SCRIPPS RESEARCH INST (US) | 2008-07-16 | — | — | CN | disclosed |
| CN-1592624-A | Substituted-triazolopyrimidines as anticancer agents | WYETH CORP (US) | 2005-03-09 | — | — | CN | disclosed |