Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 8/20 | 0.81 |
| ▸ | CASP3 | P42574 | 8/20 | 0.76 |
| ▸ | HSP90AB1 | P08238 | 4/20 | 0.76 |
| ▸ | CDC37 | Q16543 | 4/20 | 0.76 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.73 |
| ▸ | CASP1 | P29466 | 1/20 | 0.73 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | TERT | O14746 | 2/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.63 |
| ▸ | CCR6 | P51684 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22011612 | 0.94 | CASP3 (0.86) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL22010853 | 0.93 | CASP3 (0.80) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL17130183 | 0.93 | CASP3 (0.74) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL17124753 | 0.92 | CASP3 (0.73) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL18782109 | 0.92 | NR4A1 (0.68) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL18782359 | 0.89 | CASP3 (0.72) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL22011080 | 0.88 | CASP3 (0.68) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL18782341 | 0.88 | CASP3 (0.71) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL18782100 | 0.86 | CASP3 (0.65) | NR4A1CASP3HSP90AB1CDC37PTPN1 | |
| SCHEMBL12395121 | 0.86 | HSP90AB1 (1.00) | NR4A1CASP3HSP90AB1CDC37PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-11753436-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION (US) | 2023-09-12 | — | — | US | disclosed |
| US-20210061851-A1 | ANALOGS OF CELASTROL | ERX PHARMACEUTICALS CORPORATION | 2021-03-04 | — | — | US | disclosed |
| US-10662218-B2 | Analogs of celastrol | ERX PHARMACEUTICALS CORPORATION | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061851-A1 | ANALOGS OF CELASTROL | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885HSP90AB1 191/4885 |
| US-10662218-B2 | Analogs of celastrol | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885HSP90AB1 191/4885 |
| US-11753436-B2 | Analogs of celastrol | GIPR, GPR119, EBP | NR4A1 1945/4885CASP3 247/4885HSP90AB1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.