Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.31 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.31 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24978550 | 0.90 | KDM4E (0.35) | LNPEPKDM4EPOLBNAAACA1 | |
| SCHEMBL21963106 | 0.90 | LNPEP (0.34) | LNPEPKDM4EPOLBALDH1A1KMT2A | |
| SCHEMBL21963104 | 0.90 | LNPEP (0.34) | LNPEPKDM4EPOLBALDH1A1KMT2A | |
| SCHEMBL21962770 | 0.89 | KDM4E (0.36) | LNPEPKDM4EPOLBMAOAMAOB | |
| SCHEMBL21962766 | 0.89 | KDM4E (0.36) | LNPEPKDM4EPOLBMAOAMAOB | |
| SCHEMBL24978553 | 0.82 | LNPEP (0.30) | LNPEP | |
| SCHEMBL21962696 | 0.81 | LNPEP (0.34) | LNPEPKDM4EPOLBMAOAMAOB | |
| SCHEMBL24978552 | 0.81 | LNPEP (0.31) | LNPEP | |
| SCHEMBL25034083 | 0.79 | NLRP3 (0.41) | — | |
| SCHEMBL21962661 | 0.79 | HDAC3 (0.32) | LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |