Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22002744 | 0.85 | GPR35 (0.38) | GAAGPR35KMT2ASMN1; SMN2LMNA | |
| SCHEMBL22002790 | 0.81 | GPR35 (0.36) | GAAGPR35KMT2ASMN1; SMN2LMNA | |
| SCHEMBL22002677 | 0.81 | GPR35 (0.36) | GAAGPR35KMT2ASMN1; SMN2LMNA | |
| SCHEMBL22002746 | 0.80 | ABL1 (0.40) | GPR35MAPK8MAPK9ALDH1A1NLRP3 | |
| SCHEMBL7403709 | 0.79 | DYRK1A (0.45) | GAADYRK1AKDM1AIDO1KMT2A | |
| SCHEMBL27419002 | 0.78 | FABP3 (0.52) | GAAKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13592557 | 0.78 | GAA (0.52) | GAAKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22430585 | 0.77 | HPGD (0.47) | GPR35DYRK1AKDM1AIDO1SMN1; SMN2 | |
| SCHEMBL20915178 | 0.77 | GAA (0.50) | GAAKMT2ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL22868230 | 0.76 | TTR (0.31) | GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |