Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR4 | P31391 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 8/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 3/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012607 | 0.80 | CACNA1G (0.39) | HTR2CSLC6A4HTR2APIK3CAMTOR | |
| SCHEMBL22012095 | 0.78 | SSTR4 (0.39) | SSTR4HTR2CSLC6A4HTR2ABUB1 | |
| SCHEMBL22012611 | 0.78 | CACNA1G (0.39) | HTR2CSLC6A4HTR2AGPR119CACNA1G | |
| SCHEMBL18789182 | 0.77 | POLB (0.44) | BUB1CDK9PIK3CAMTORGPR119 | |
| SCHEMBL21990463 | 0.74 | NR1H2 (0.38) | PIK3CAMTOR | |
| SCHEMBL18789177 | 0.70 | PIK3CA (0.46) | SLC6A4UGCGPIK3CAMTOR | |
| SCHEMBL5775309 | 0.70 | SSTR4 (0.38) | SSTR4HTR2CSLC6A4HTR2ABUB1 | |
| SCHEMBL29814890 | 0.69 | CAMKK1 (0.36) | SLC6A4UGCG | |
| SCHEMBL30701033 | 0.68 | BUB1 (0.43) | BUB1PIK3CAMTORGPR119 | |
| SCHEMBL5775139 | 0.68 | HTR2C (0.44) | HTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| WO-2020100027-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2020-05-22 | — | — | WO | disclosed |