Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22012277 | 0.85 | CACNA1G (0.37) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL30500363 | 0.85 | CACNA1G (0.37) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL30136111 | 0.85 | CACNA1G (0.37) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL22012577 | 0.85 | CACNA1G (0.37) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL21990476 | 0.82 | CACNA1G (0.38) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL30227881 | 0.82 | CACNA1G (0.35) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL21990508 | 0.82 | CACNA1G (0.35) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL30913142 | 0.80 | CACNA1G (0.34) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL22012095 | 0.79 | SSTR4 (0.39) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 | |
| SCHEMBL22012607 | 0.79 | CACNA1G (0.39) | CACNA1GCACNA1BCACNA1CHTR2CSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880676-B1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER (US) | 2023-08-02 | — | — | EP | disclosed |
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | PFIZER INC. (US) | 2021-10-12 | — | — | US | disclosed |
| WO-2020100027-A1 | 2,3-DIHYDRO-1H-PYRROLO[3,4-C]PYRIDIN-1-ONE DERIVATIVES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | PFIZER INC. (US) | 2020-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11142525-B2 | Azalactam compounds as HPK1 inhibitors | CDKN1A, HIPK1, CMPK1 | CACNA1G 4323/4885CACNA1B 4420/4885CACNA1C 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.