Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.71 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | XBP1 | P17861 | 1/20 | 0.71 |
| ▸ | CLK1 | P49759 | 1/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.71 |
| ▸ | TDP2 | O95551 | 1/20 | 0.61 |
| ▸ | STAT3 | P40763 | 3/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28603098 | 0.99 | ALDH1A1 (0.70) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL31320231 | 0.99 | ALDH1A1 (0.70) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL15840789 | 0.88 | ALDH1A1 (0.74) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL21964225 | 0.84 | MAPT (0.70) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL19385517 | 0.83 | MAPT (1.00) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| Phosphoric Acid SCHEMBL31320273 | 0.83 | MAPT (0.65) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL28595390 | 0.81 | MAPT (0.75) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL28600039 | 0.80 | MAPT (0.74) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL28600044 | 0.79 | MAPT (0.75) | ALDH1A1MAPTRAB9AKMT2ALMNA | |
| SCHEMBL2465457 | 0.74 | ALDH1A1 (0.77) | ALDH1A1MAPTRAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113226323-B | Ma Dexin derivative compounds, compositions and uses thereof for the treatment of cancer | 法国古士塔柏罗斯学院 | 2024-12-31 | — | — | CN | disclosed |
| EP-3880205-B1 | MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER | ROUSSY INST GUSTAVE (FR) | 2023-08-30 | — | — | EP | disclosed |
| EP-3880205-B1 | MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER | ROUSSY INST GUSTAVE (FR) | 2023-08-30 | — | — | EP | disclosed |
| CN-113226323-A | Madricin derivative compounds, compositions and uses thereof for treating cancer | 法国古士塔柏罗斯学院 | 2021-08-06 | — | — | CN | disclosed |
| WO-2020099650-A1 | MADRASIN-DERIVATIVE COMPOUNDS, COMPOSITION AND USES THEREOF FOR TREATING CANCER | INSTITUT GUSTAVE ROUSSY (FR) | 2020-05-22 | — | — | WO | disclosed |