Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.75 |
| ▸ | RAB9A | P51151 | 4/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.75 |
| ▸ | HTT | P42858 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.75 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | XBP1 | P17861 | 1/20 | 0.75 |
| ▸ | CLK1 | P49759 | 1/20 | 0.75 |
| ▸ | TDP2 | O95551 | 1/20 | 0.62 |
| ▸ | STAT3 | P40763 | 3/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28595390 | 0.90 | MAPT (0.75) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL28600039 | 0.89 | MAPT (0.74) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL19385517 | 0.86 | MAPT (1.00) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL21964225 | 0.82 | MAPT (0.70) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL15840789 | 0.81 | ALDH1A1 (0.74) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL22013244 | 0.79 | ALDH1A1 (0.71) | MAPTALDH1A1RAB9ALMNANPC1 | |
| Phosphoric Acid SCHEMBL31320273 | 0.79 | MAPT (0.65) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL31320231 | 0.78 | ALDH1A1 (0.70) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL28603098 | 0.78 | ALDH1A1 (0.70) | MAPTALDH1A1RAB9ALMNANPC1 | |
| SCHEMBL21964142 | 0.74 | RAB9A (0.63) | MAPTALDH1A1RAB9ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12213978-B2 | Madrasin-derivative compounds, composition and uses thereof for treating cancer | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2025-02-04 | — | — | US | claimed |
| CN-113226323-A | Madricin derivative compounds, compositions and uses thereof for treating cancer | 法国古士塔柏罗斯学院 | 2021-08-06 | — | — | CN | claimed |
| US-12213978-B2 | Madrasin-derivative compounds, composition and uses thereof for treating cancer | INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) | 2025-02-04 | — | — | US | disclosed |
| CN-113226323-A | Madricin derivative compounds, compositions and uses thereof for treating cancer | 法国古士塔柏罗斯学院 | 2021-08-06 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12213978-B2 | Madrasin-derivative compounds, composition and uses thereof for treating cancer | PTPRS, PTMS, PTPRC | MAPT 1578/4885ALDH1A1 1922/4885RAB9A 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.