Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962214 | 0.86 | HRH3 (0.48) | HRH3HRH4GPR119KCNH2RORC | |
| SCHEMBL22013625 | 0.77 | HRH3 (0.39) | HRH3HRH4GPR119KCNH2LMNA | |
| SCHEMBL22012518 | 0.76 | HRH3 (0.54) | HRH3HRH4KCNH2PARP1SLC6A2 | |
| SCHEMBL21962543 | 0.76 | HRH3 (0.38) | HRH3HRH4GPR119KCNH2RORC | |
| SCHEMBL20698762 | 0.69 | CA2 (0.43) | HRH3LMNASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20680948 | 0.68 | CA2 (0.49) | HRH3SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL29957867 | 0.68 | HRH3 (0.55) | HRH3HRH4KCNH2LMNAMAPT | |
| SCHEMBL6618848 | 0.65 | HRH3 (0.45) | HRH3HRH4KCNH2PARP1SLC6A2 | |
| SCHEMBL13452623 | 0.65 | HRH3 (0.59) | HRH3HRH4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13649128 | 0.64 | HRH3 (0.74) | HRH3HRH4KCNH2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |