Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 15/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866811 | 0.96 | NLRP3 (0.57) | NLRP3ATMSMN1; SMN2ALDH1A1BAZ2B | |
| SCHEMBL20194506 | 0.92 | NLRP3 (0.53) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL20681634 | 0.83 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL22012162 | 0.81 | NLRP3 (0.50) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL30852987 | 0.80 | NLRP3 (0.63) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL19791959 | 0.79 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL20412501 | 0.79 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL28424800 | 0.79 | NLRP3 (0.51) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL20713466 | 0.79 | NLRP3 (0.54) | NLRP3ATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL29804891 | 0.78 | NLRP3 (0.61) | NLRP3ATMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |