Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.42 |
| ▸ | ACVR2A | P27037 | 5/20 | 0.41 |
| ▸ | TGFBR2 | P37173 | 5/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962143 | 0.84 | NLRP3 (0.45) | NLRP3ACVR2ATGFBR2IDO1 | |
| SCHEMBL21962099 | 0.83 | NLRP3 (0.44) | NLRP3ACVR2ATGFBR2IDO1 | |
| SCHEMBL28634299 | 0.83 | NLRP3 (0.44) | NLRP3ACVR2ATGFBR2IDO1PDE4B | |
| SCHEMBL21962081 | 0.83 | NLRP3 (0.46) | NLRP3ACVR2ATGFBR2IDO1 | |
| SCHEMBL24478079 | 0.82 | ACVR2A (0.44) | NLRP3ACVR2ATGFBR2IDO1PDCD1 | |
| SCHEMBL22827545 | 0.82 | PDCD1 (0.47) | NLRP3ACVR2ATGFBR2IDO1PDCD1 | |
| SCHEMBL21646547 | 0.82 | NLRP3 (0.51) | NLRP3ACVR2ATGFBR2TGFBR1DYRK1A | |
| SCHEMBL23063148 | 0.81 | NLRP3 (0.45) | NLRP3ACVR2ATGFBR2IDO1PDCD1 | |
| SCHEMBL25144807 | 0.81 | ACVR2A (0.43) | NLRP3ACVR2ATGFBR2IDO1PDCD1 | |
| SCHEMBL25031249 | 0.78 | TLR9 (0.39) | AAK1TLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |