Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 6/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962143 | 0.90 | NLRP3 (0.45) | NLRP3PKN1PKN2IDO1LPAR1 | |
| SCHEMBL21962099 | 0.89 | NLRP3 (0.44) | NLRP3PKN1PKN2IDO1LPAR1 | |
| SCHEMBL21962081 | 0.89 | NLRP3 (0.46) | NLRP3PKN1PKN2IDO1LPAR1 | |
| SCHEMBL22014327 | 0.83 | NLRP3 (0.42) | NLRP3IDO1ACVR2ATGFBR2PDE4B | |
| SCHEMBL25067031 | 0.80 | FFAR1 (0.39) | NLRP3LPAR1WNT3A | |
| SCHEMBL23063148 | 0.78 | NLRP3 (0.45) | NLRP3PKN1PKN2IDO1CNR1 | |
| SCHEMBL25144807 | 0.78 | ACVR2A (0.43) | NLRP3PKN1PKN2IDO1ACVR2A | |
| SCHEMBL24787851 | 0.78 | ACACB (0.40) | NLRP3PKN2CDK5 | |
| SCHEMBL23012916 | 0.77 | FFAR1 (0.37) | NLRP3LPAR1WNT3A | |
| SCHEMBL29691434 | 0.77 | FFAR1 (0.37) | NLRP3LPAR1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227055-A | Compounds and compositions for treating conditions associated with NLRP activity | 诺华股份有限公司 | 2021-08-06 | — | — | CN | disclosed |