Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 18/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201440 | 1.00 | CCR2 (0.48) | CCR2KMT2ACCR5KCNH2 | |
| SCHEMBL2201437 | 1.00 | CCR2 (0.48) | CCR2KMT2ACCR5KCNH2 | |
| SCHEMBL12429649 | 1.00 | CCR2 (0.48) | CCR2KMT2ACCR5KCNH2 | |
| SCHEMBL2201648 | 0.88 | KMT2A (0.49) | KMT2A | |
| SCHEMBL2203346 | 0.84 | KMT2A (0.45) | KMT2A | |
| SCHEMBL2203058 | 0.84 | KMT2A (0.52) | KMT2A | |
| SCHEMBL2202045 | 0.80 | KMT2A (0.47) | KMT2A | |
| SCHEMBL2199925 | 0.79 | KMT2A (0.50) | KMT2A | |
| SCHEMBL14848998 | 0.77 | CCR2 (0.72) | CCR2CCR5KCNH2 | |
| SCHEMBL2197635 | 0.77 | KMT2A (0.53) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977358-B2 | Pyrazol derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-20090029963-A1 | PYRAZOL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029963-A1 | PYRAZOL DERIVATIVES | CCR1, CCR3, CCRL2 | CCR2 5/4885KMT2A 4057/4885CCR5 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.