Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21962077 | 0.88 | RXRB (0.43) | MEN1KMT2AMETAP2RXRBRXRA | |
| SCHEMBL21962126 | 0.86 | MEN1 (0.39) | MEN1KMT2AMETAP2RXRBRXRA | |
| SCHEMBL21962078 | 0.79 | MTNR1A (0.45) | POLBMEN1KMT2AMETAP2RXRB | |
| SCHEMBL30150902 | 0.76 | MEN1 (0.34) | MEN1KMT2ARXRBRXRARXRG | |
| SCHEMBL20698988 | 0.73 | ALDH1A1 (0.41) | ATMALDH1A1 | |
| SCHEMBL22775438 | 0.72 | ALDH1A1 (0.40) | ATMALDH1A1 | |
| SCHEMBL21962255 | 0.72 | BCHE (0.42) | ALDH1A1PARP1 | |
| SCHEMBL25067101 | 0.71 | KMT2A (0.39) | KMT2AMETAP2RXRBRXRARXRG | |
| SCHEMBL30150923 | 0.69 | RXRB (0.43) | MEN1KMT2ARXRBRXRARXRG | |
| SCHEMBL27801796 | 0.69 | ALDH1A1 (0.48) | POLBMEN1KMT2AALDH1A1BCAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |