Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12950802 | 0.87 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL22015157 | 0.87 | KMT2A (0.46) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL22013976 | 0.86 | KMT2A (0.45) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL22015172 | 0.81 | KMT2A (0.43) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL22013979 | 0.80 | KMT2A (0.44) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL14818761 | 0.79 | SMN1; SMN2 (0.57) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL14502145 | 0.76 | SMN1; SMN2 (0.51) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| Hydrochloric Acid SCHEMBL21640362 | 0.74 | SMN1; SMN2 (0.52) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL7368441 | 0.69 | L3MBTL1 (0.69) | KMT2AMEN1SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1558713 | 0.69 | RAB9A (0.70) | KMT2ASMN1; SMN2LMNAL3MBTL1SORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020099885-A1 | HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS | THE UNIVERSITY OF SHEFFIELD (GB) | 2020-05-22 | — | — | WO | disclosed |