Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850779 | 0.82 | NFE2L2 (0.43) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL29387155 | 0.73 | CA1 (0.50) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL196734 | 0.73 | CA1 (0.50) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL29466747 | 0.72 | — | — | |
| SCHEMBL7027663 | 0.72 | — | — | |
| SCHEMBL22390 | 0.72 | — | — | |
| SCHEMBL29669870 | 0.71 | NFE2L2 (0.50) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL256786 | 0.71 | NFE2L2 (0.48) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL1627720 | 0.71 | NFE2L2 (0.50) | NFE2L2L3MBTL1TDP1CA12CA1 | |
| SCHEMBL27340979 | 0.71 | NFE2L2 (0.48) | NFE2L2L3MBTL1TDP1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102730-A1 | IMPROVED SYNTHESIS OF KEY INTERMEDIATE OF KRAS G12C INHIBITOR COMPOUND | AMGEN INC. (US) | 2020-05-22 | — | — | WO | disclosed |