Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21672110 | 0.94 | MPO (0.39) | MPONLRP3IRAK4HDAC1HDAC8 | |
| SCHEMBL22019996 | 0.89 | MPO (0.35) | MPONLRP3HDAC1HDAC8HDAC6 | |
| SCHEMBL23762860 | 0.75 | LRRK2 (0.37) | — | |
| SCHEMBL25033609 | 0.73 | CNR2 (0.33) | MPONLRP3HDAC1HDAC8HDAC6 | |
| SCHEMBL2054538 | 0.72 | MPO (0.42) | MPONLRP3IRAK4HDAC1HDAC8 | |
| SCHEMBL18338520 | 0.72 | MPO (0.42) | MPONLRP3IRAK4HDAC1HDAC8 | |
| SCHEMBL23762573 | 0.70 | — | — | |
| SCHEMBL23762818 | 0.70 | — | — | |
| SCHEMBL23762921 | 0.70 | — | — | |
| SCHEMBL22012273 | 0.70 | NLRP3 (0.35) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |