SCHEMBL22015055

SCHEMBL22015055

O=C(O)c1nnsc1-c1ncco1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2C9 P11712 1/20 0.53
HSD17B10 Q99714 1/20 0.53
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
KDM4E B2RXH2 2/20 0.34
ASPH Q12797 1/20 0.34
KDM8 Q8N371 1/20 0.34
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
ALOX15 P16050 1/20 0.33
TSHR P16473 1/20 0.33
BLM P54132 1/20 0.33
AGER Q15109 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAPK8 P45983 1/20 0.32
MAPK9 P45984 1/20 0.32
MAPK10 P53779 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28459432 0.74 HPGDS (0.33) HPGDSLTA4H
SCHEMBL21963666 0.73 ALDH1A1 (0.59) ALDH1A1CYP1A2CYP2C9HSD17B10MEN1
SCHEMBL22322877 0.68 CYP1A2 (0.79) ALDH1A1CYP1A2CYP2C9HSD17B10MEN1
SCHEMBL6816387 0.68 ALDH1A1 (0.67) ALDH1A1CYP1A2CYP2C9HSD17B10MEN1
SCHEMBL2213807 0.67 ALDH1A1 (0.85) ALDH1A1CYP1A2CYP2C9HSD17B10MEN1
SCHEMBL29479690 0.66 KDM4E (0.53) ALDH1A1CYP1A2KDM4EASPHKDM8
SCHEMBL31165963 0.65 KDM4E (0.57) ALDH1A1KDM4EASPHKDM8CYP3A4
SCHEMBL13771876 0.65 ALDH1A1 (0.58) ALDH1A1CYP1A2CYP2C9HSD17B10MEN1
SCHEMBL16031447 0.64 HCRTR2 (0.44) ALDH1A1KDM4EASPHKDM8CYP3A4
SCHEMBL31165930 0.62 KDM4E (0.39) KDM4EASPHKDM8HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020099404-A1 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2020-05-22 WO disclosed