Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.36 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25066905 | 0.91 | NLRP3 (0.36) | NLRP3LSSSMYD3TAS2R14STAT3 | |
| SCHEMBL25067028 | 0.91 | NLRP3 (0.36) | NLRP3LSSSMYD3TAS2R14STAT3 | |
| SCHEMBL22014337 | 0.91 | NLRP3 (0.36) | NLRP3LSSSMYD3TAS2R14STAT3 | |
| SCHEMBL20698685 | 0.83 | NLRP3 (0.31) | NLRP3 | |
| SCHEMBL22015051 | 0.82 | SLC6A2 (0.31) | NLRP3SLC6A2SLC6A4 | |
| SCHEMBL22014366 | 0.82 | NLRP3 (0.33) | NLRP3 | |
| SCHEMBL20698803 | 0.82 | NLRP3 (0.33) | NLRP3 | |
| SCHEMBL23668409 | 0.82 | NLRP3 (0.44) | NLRP3LSSSMYD3TAS2R14STAT3 | |
| SCHEMBL29687811 | 0.82 | NLRP3 (0.44) | NLRP3LSSSMYD3TAS2R14STAT3 | |
| SCHEMBL29687146 | 0.82 | NLRP3 (0.44) | NLRP3LSSSMYD3TAS2R14STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658538-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-04-19 | — | — | EP | disclosed |
| WO-2020102574-A1 | THE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |