Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | RORA | P35398 | 8/20 | 0.46 |
| ▸ | RORC | P51449 | 8/20 | 0.46 |
| ▸ | RORB | Q92753 | 8/20 | 0.46 |
| ▸ | PGR | P06401 | 7/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22031980 | 0.84 | PGR (0.49) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL22035261 | 0.81 | ATM (0.41) | SRCKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL21979038 | 0.80 | PGR (0.46) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL30901347 | 0.80 | PGR (0.46) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL18015724 | 0.80 | KIF11 (0.50) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL22017354 | 0.78 | PGR (0.44) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL31223920 | 0.77 | PGR (0.46) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL16729412 | 0.76 | KIF11 (0.51) | CYP2C9PGRNR1H3KIF11SRC | |
| SCHEMBL27857916 | 0.74 | PGR (0.74) | CYP2C9RORARORCRORBPGR | |
| SCHEMBL13383054 | 0.73 | KIF11 (0.65) | CYP2C9RORARORCRORBPGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | CYP2C9 823/4885RORA 488/4885RORC 150/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | CYP2C9 823/4885RORA 488/4885RORC 150/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | CYP2C9 823/4885RORA 488/4885RORC 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.