Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8878783 | 0.82 | TDP1 (0.51) | CYP1A2SMN1; SMN2CYP2C19HRH1TDP1 | |
| SCHEMBL9288931 | 0.80 | CYP1A2 (0.49) | CYP1A2SMN1; SMN2CYP2C19KMT2AHRH1 | |
| SCHEMBL4560574 | 0.79 | MAPT (0.52) | CYP1A2CYP2C19KMT2AMAPTKCNH2 | |
| SCHEMBL6532240 | 0.78 | CYP1A2 (0.58) | CYP1A2SMN1; SMN2CYP2C19KMT2AHRH1 | |
| SCHEMBL13859429 | 0.77 | CYP1A2 (0.50) | CYP1A2CYP2C19KMT2AHRH1ALOX15 | |
| SCHEMBL8503990 | 0.77 | CYP1A2 (0.70) | CYP1A2SMN1; SMN2CYP2C19HRH1TDP1 | |
| SCHEMBL2749938 | 0.77 | CYP1A2 (0.53) | CYP1A2SMN1; SMN2CYP2C19KMT2AHRH1 | |
| SCHEMBL8862654 | 0.76 | FDPS (0.47) | CYP1A2SMN1; SMN2CYP2C19KMT2APGR | |
| SCHEMBL27535192 | 0.75 | CYP1A2 (0.56) | CYP1A2SMN1; SMN2CYP2C19KMT2AHRH1 | |
| SCHEMBL528412 | 0.75 | KMT2A (0.55) | CYP1A2CYP2C19KMT2AMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | AMGEN INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166132-A1 | Gamma Secretase Modulators | BACE1, BACE2, PSEN1 | CYP1A2 4099/4885SMN1; SMN2 1335/4885CYP2C19 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.