Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22017069 | 0.86 | LMNA (0.61) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL28626479 | 0.84 | MAPT (0.69) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL31555681 | 0.84 | MAPT (0.69) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL6743212 | 0.84 | KMT2A (0.51) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL6743215 | 0.84 | KMT2A (0.51) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL17395927 | 0.83 | HTT (0.46) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL17395926 | 0.83 | HTT (0.46) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL31105648 | 0.83 | HTT (0.46) | NPC1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL16993762 | 0.83 | MAPT (0.53) | KMT2AL3MBTL1MEN1POLBMAPT | |
| SCHEMBL16993761 | 0.83 | MAPT (0.53) | KMT2AL3MBTL1MEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3164123-B1 | NOVEL THERAPEUTIC USES OF BENZYLIDENEGUANIDINE DERIVATIVES FOR THE TREATMENT OF PROTEOPATHIES | INFLECTIS BIOSCIENCE (FR) | 2020-05-20 | — | — | EP | disclosed |