Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.45 |
| ▸ | DPYD | Q12882 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1918404 | 0.79 | ATAD2 (0.52) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL28185766 | 0.78 | ATAD2 (0.42) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL887700 | 0.76 | ATAD2 (0.48) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL8933555 | 0.76 | GAA (0.48) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL17060272 | 0.73 | ATAD2 (0.45) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL7255538 | 0.73 | ATAD2 (0.45) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL16893950 | 0.73 | GAA (0.54) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL31318804 | 0.72 | DPYD (0.48) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL7598527 | 0.72 | HTR2A (0.45) | ATAD2DPYDGAAMAPTALDH1A1 | |
| SCHEMBL28699194 | 0.72 | GAA (0.44) | ATAD2DPYDGAAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ATAD2 1012/4885DPYD 1232/4885GAA 252/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | ATAD2 1012/4885DPYD 1232/4885GAA 252/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | ATAD2 1012/4885DPYD 1232/4885GAA 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.