Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29407515 | 1.00 | FEN1 (0.60) | FEN1ALDH1A1LOXL3LOXL2AURKA | |
| SCHEMBL12372609 | 0.81 | DAO (0.58) | FEN1ALDH1A1AURKAPARP1DAO | |
| SCHEMBL1713792 | 0.79 | FEN1 (0.66) | FEN1ALDH1A1LOXL3LOXL2AURKA | |
| SCHEMBL22017499 | 0.76 | LMNA (0.39) | FEN1ALDH1A1AURKAMAPTKDM4E | |
| SCHEMBL8145246 | 0.76 | FEN1 (1.00) | FEN1ALDH1A1LOXL3LOXL2AURKA | |
| SCHEMBL24312097 | 0.75 | ADORA3 (0.47) | PARP1MAPTKDM4EDAO | |
| SCHEMBL22017504 | 0.75 | GRM4 (0.40) | FEN1ALDH1A1MAPTKDM4EGRM4 | |
| SCHEMBL1713392 | 0.75 | FEN1 (0.60) | FEN1ALDH1A1MAPTKDM4EPKM | |
| SCHEMBL11865926 | 0.75 | FEN1 (0.60) | FEN1ALDH1A1LOXL3LOXL2AURKA | |
| SCHEMBL7650487 | 0.73 | ADORA3 (0.61) | FEN1ALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3969450-B1 | QUINAZOLINE-2,4-DIONE DERIVATIVES AS PARP INHIBITORS | SUZHOU FOUR HEALTH PHARMACEUTICALS CO LTD (CN) | 2023-10-25 | — | — | EP | disclosed |
| US-20230041518-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-02-09 | — | — | US | disclosed |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
| US-11116760-B2 | Quinoline derivatives | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| WO-2020229595-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES AS PARP INHIBITORS | MOLECULAR TARGETED RADIOPHARMACEUTICALS HOLDING GMBH (MTR) (DE) | 2020-11-19 | — | — | WO | disclosed |
| WO-2020229595-A1 | QUINAZOLINE-2,4-DIONE DERIVATIVES AS PARP INHIBITORS | MOLECULAR TARGETED RADIOPHARMACEUTICALS HOLDING GMBH (MTR) (DE) | 2020-11-19 | — | — | WO | disclosed |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230041518-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | FEN1 4719/4885ALDH1A1 476/4885LOXL3 3090/4885 |
| US-20200155538-A1 | QUINOLINE DERIVATIVES | CFTR, NQO1, IRF3 | FEN1 4719/4885ALDH1A1 476/4885LOXL3 3090/4885 |
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | FEN1 4828/4885ALDH1A1 838/4885LOXL3 2670/4885 |
| US-11116760-B2 | Quinoline derivatives | CFTR, NQO1, IRF3 | FEN1 4719/4885ALDH1A1 476/4885LOXL3 3090/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.