Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 5/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 10/20 | 0.50 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28537925 | 0.91 | TMPRSS2 (0.58) | TMPRSS2POLBCTDSP1MAPTMEN1 | |
| SCHEMBL22017771 | 0.84 | MAPT (0.47) | MAPTMEN1KMT2AHTTLMNA | |
| SCHEMBL22017401 | 0.82 | TMPRSS2 (0.68) | TMPRSS2POLBMAPTLMNA | |
| SCHEMBL22017753 | 0.81 | TMPRSS2 (0.87) | TMPRSS2POLBMAPTMEN1KMT2A | |
| SCHEMBL28547627 | 0.81 | MAPT (0.55) | POLBCTDSP1MAPTMEN1KMT2A | |
| SCHEMBL22017242 | 0.81 | TMPRSS2 (0.65) | TMPRSS2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL10092719 | 0.80 | MAPT (0.59) | POLBMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL22017757 | 0.80 | TMPRSS2 (0.67) | TMPRSS2POLBMAPTLMNA | |
| SCHEMBL22017407 | 0.80 | TMPRSS2 (0.66) | TMPRSS2POLBMAPTLMNA | |
| SCHEMBL22017408 | 0.79 | TMPRSS2 (0.79) | TMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109503518-B | Substituted biaryl amide compound and preparation method and application thereof | 中国医学科学院医药生物技术研究所 | 2021-03-30 | — | — | CN | disclosed |
| WO-2020098710-A1 | SUBSTITUTED BIS-ARYL AMIDE COMPOUND AND PREPARATION METHOD AND APPLICATION THEREFOR | 中国医学科学院医药生物技术研究所 | 2020-05-22 | — | — | WO | disclosed |
| CN-109503518-A | A kind of substituted double aromatic radical amide compounds and its preparation method and application | 中国医学科学院医药生物技术研究所 | 2019-03-22 | — | — | CN | disclosed |