Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 4/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | EED | O75530 | 1/20 | 0.35 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.35 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.35 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.35 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20691645 | 0.90 | DRD3 (0.43) | DRD3DRD4NR1H2NR1H3UCHL1 | |
| SCHEMBL22615358 | 0.88 | MEN1 (0.39) | SPRGPR119HDAC1MAP4K4ELANE | |
| SCHEMBL20691685 | 0.88 | MEN1 (0.39) | SPRGPR119HDAC1MAP4K4ELANE | |
| SCHEMBL17936948 | 0.86 | SPR (0.36) | DRD3DRD4SPRGPR119HDAC1 | |
| SCHEMBL21058315 | 0.85 | GPR119 (0.38) | NR1H2SPRGPR119HDAC1MAP4K4 | |
| SCHEMBL19632326 | 0.85 | GPR119 (0.38) | NR1H2SPRGPR119HDAC1MAP4K4 | |
| SCHEMBL21260292 | 0.84 | GPR119 (0.37) | SPRGPR119HDAC1MAP4K4ELANE | |
| SCHEMBL21058322 | 0.83 | HDAC1 (0.38) | SPRGPR119HDAC1MAP4K4TSHR | |
| SCHEMBL19632286 | 0.83 | HDAC1 (0.38) | SPRGPR119HDAC1MAP4K4TSHR | |
| SCHEMBL17925539 | 0.83 | HDAC1 (0.39) | NR1H2SPRGPR119HDAC1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109952305-B | Piperazino heteroaryl derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-06-21 | — | — | CN | disclosed |
| US-11247998-B2 | Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2022-02-15 | — | — | US | disclosed |
| US-20200157111-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247998-B2 | Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine | IKZF2, WEE1, NOTUM | DRD3 4462/4885DRD4 4402/4885NR1H2 183/4885 |
| US-20200157111-A1 | PIPERAZINE HETEROARYL DERIVATIVE, PREPARATION METHOD THEREFOR AND USE OF SAME IN MEDICINE | IKZF2, WEE1, NOTUM | DRD3 4462/4885DRD4 4402/4885NR1H2 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.