Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15883632 | 0.84 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL600704 | 0.84 | ALDH1A1 (0.67) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL9920357 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL22018175 | 0.81 | CAMKK1 (0.46) | ALDH1A1KDM4ESMN1; SMN2HPGDRAB9A | |
| SCHEMBL9920355 | 0.81 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13212873 | 0.80 | ALDH1A1 (0.54) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL9052351 | 0.75 | ALDH1A1 (0.64) | ALDH1A1KDM4ESMN1; SMN2HPGDRAB9A | |
| SCHEMBL31338931 | 0.75 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL3183698 | 0.74 | TSHR (0.54) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL13213080 | 0.74 | ALDH1A1 (0.56) | ALDH1A1KDM4EHSD17B10SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828290-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20200155527-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORPORATION | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155527-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM2, PIM1, PIM3 | ALDH1A1 1912/4885KDM4E 913/4885HSD17B10 3416/4885 |
| US-10828290-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors | PIM2, PIM1, PIM3 | ALDH1A1 1912/4885KDM4E 913/4885HSD17B10 3416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.