Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.46 |
| ▸ | EPHB3 | P54753 | 7/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416200 | 0.82 | EPHB3 (0.56) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL22018174 | 0.81 | ALDH1A1 (0.54) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL30152645 | 0.80 | EPHB3 (0.55) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| Hydrochloric Acid SCHEMBL19119427 | 0.80 | EPHB3 (0.55) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL15883629 | 0.79 | NPC1 (0.50) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL15399063 | 0.79 | NPC1 (0.45) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL12493142 | 0.78 | EPHB3 (0.49) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL22853734 | 0.77 | CAMKK1 (0.39) | CAMKK1CAMKK2EPHB3RIPK2LCK | |
| SCHEMBL18399563 | 0.76 | MAP4K4 (0.43) | CAMKK1CAMKK2EPHB3NPC1RAB9A | |
| SCHEMBL22018172 | 0.75 | IDO1 (0.52) | EPHB3RIPK2LCKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10828290-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20200155527-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE HOLDINGS CORPORATION | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155527-A1 | THIAZOLECARBOXAMIDES AND PYRIDINECARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM2, PIM1, PIM3 | CAMKK1 331/4885CAMKK2 330/4885EPHB3 4255/4885 |
| US-10828290-B2 | Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors | PIM2, PIM1, PIM3 | CAMKK1 331/4885CAMKK2 330/4885EPHB3 4255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.