Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19767693 | 0.80 | TP53BP1 (0.43) | KMT2AMEN1CNR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL20806673 | 0.79 | TP53BP1 (0.37) | KMT2AMEN1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL24098231 | 0.79 | ALDH1A1 (0.42) | KMT2AMEN1CNR1SMN1; SMN2TP53 | |
| SCHEMBL22305527 | 0.79 | KMT2A (0.42) | KMT2AMEN1CNR1SMN1; SMN2TP53 | |
| SCHEMBL23790074 | 0.79 | KDM4E (0.59) | KMT2AMEN1SMN1; SMN2ALDH1A1CASP2 | |
| SCHEMBL25443800 | 0.79 | KMT2A (0.42) | KMT2AMEN1CNR1SMN1; SMN2TP53 | |
| SCHEMBL20805238 | 0.79 | MEN1 (0.42) | KMT2AMEN1SMN1; SMN2ALDH1A1CASP2 | |
| SCHEMBL20438625 | 0.78 | CNR1 (0.35) | KMT2AMEN1CNR1SMN1; SMN2TP53 | |
| SCHEMBL18313728 | 0.77 | ALDH1A1 (0.52) | KMT2AMEN1CNR1SMN1; SMN2TP53 | |
| SCHEMBL23975259 | 0.77 | POLB (0.42) | KMT2AMEN1SMN1; SMN2ALDH1A1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2021-11-30 | — | — | US | disclosed |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2021-04-15 | — | — | US | disclosed |
| US-10660968-B2 | Spirocyclic degronimers for target protein degradation | C4 THERAPEUTICS, INC. (US) | 2020-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11185592-B2 | Spirocyclic degronimers for target protein degradation | STUB1, UBE3C, UBE3A | KMT2A 2852/4885MEN1 1630/4885CNR1 3820/4885 |
| US-20210106688-A1 | SPIROCYCLIC DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | STUB1, UBE3C, UBE3A | KMT2A 2852/4885MEN1 1630/4885CNR1 3820/4885 |
| US-10660968-B2 | Spirocyclic degronimers for target protein degradation | STUB1, UBE3C, UBE3A | KMT2A 2852/4885MEN1 1630/4885CNR1 3820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.